BRAIN NETWORKS. Correlated gene expression supports synchronous activity in brain networks.

TitleBRAIN NETWORKS. Correlated gene expression supports synchronous activity in brain networks.
Publication TypeJournal Article
Year of Publication2015
AuthorsRichiardi J, Altmann A, Milazzo A-C, Chang C, M Chakravarty M, Banaschewski T, Barker GJ, Bokde ALW, Bromberg U, Büchel C, Conrod P, Fauth-Bühler M, Flor H, Frouin V, Gallinat J, Garavan H, Gowland P, Heinz A, Lemaître H, Mann KF, Martinot J-L, Nees F, Paus T, Pausova Z, Rietschel M, Robbins TW, Smolka MN, Spanagel R, Ströhle A, Schumann G, Hawrylycz M, Poline J-B, Greicius MD
Corporate AuthorsIMAGEN consortium
JournalScience
Volume348
Issue6240
Pagination1241-4
Date Published2015 Jun 12
ISSN1095-9203
KeywordsAdolescent, Adult, Animals, Brain, Female, Gene Expression, Humans, Ion Channels, Magnetic Resonance Imaging, Male, Mice, Nerve Net, Neural Pathways, Polymorphism, Genetic, Rest, Synapses, Transcriptome, Young Adult
Abstract

During rest, brain activity is synchronized between different regions widely distributed throughout the brain, forming functional networks. However, the molecular mechanisms supporting functional connectivity remain undefined. We show that functional brain networks defined with resting-state functional magnetic resonance imaging can be recapitulated by using measures of correlated gene expression in a post mortem brain tissue data set. The set of 136 genes we identify is significantly enriched for ion channels. Polymorphisms in this set of genes significantly affect resting-state functional connectivity in a large sample of healthy adolescents. Expression levels of these genes are also significantly associated with axonal connectivity in the mouse. The results provide convergent, multimodal evidence that resting-state functional networks correlate with the orchestrated activity of dozens of genes linked to ion channel activity and synaptic function.

DOI10.1126/science.1255905
Alternate JournalScience
PubMed ID26068849
PubMed Central IDPMC4829082
Grant List93558 / / Medical Research Council / United Kingdom
R01 NS073498 / NS / NINDS NIH HHS / United States
/ / Department of Health / United Kingdom
R01 MH085772 / MH / NIMH NIH HHS / United States
R01NS073498 / NS / NINDS NIH HHS / United States
U54 EB020403 / EB / NIBIB NIH HHS / United States
R01 MH085772-01A1 / MH / NIMH NIH HHS / United States
/ / Wellcome Trust / United Kingdom

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