Astrocyte Biomarkers in Alzheimer's Disease.

TitleAstrocyte Biomarkers in Alzheimer's Disease.
Publication TypeJournal Article
Year of Publication2019
AuthorsCarter SF, Herholz K, Rosa-Neto P, Pellerin L, Nordberg A, Zimmer ER
JournalTrends Mol Med
Date Published2019 Jan 02
ISSN1471-499X
Abstract

Astrocytic contributions to Alzheimer's disease (AD) progression were, until recently, largely overlooked. Astrocytes are integral to normal brain function and astrocyte reactivity is an early feature of AD, potentially providing a promising target for preclinical diagnosis and treatment. Several in vivo AD biomarkers already exist, but presently there is a paucity of specific and sensitive in vivo astrocyte biomarkers that can accurately measure preclinical AD. Measuring monoamine oxidase-B with neuroimaging and glial fibrillary acidic protein from bodily fluids are biomarkers that are currently available. Developing novel, more specific, and sensitive astrocyte biomarkers will make it possible to pharmaceutically target chemical pathways that preserve beneficial astrocytic functions in response to AD pathology. This review discusses astrocyte biomarkers in the context of AD.

DOI10.1016/j.molmed.2018.11.006
Alternate JournalTrends Mol Med
PubMed ID30611668


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