Association between clinical symptoms and apolipoprotein A1 or apolipoprotein B levels is regulated by apolipoprotein E variant rs429358 in patients with chronic schizophrenia.

TitleAssociation between clinical symptoms and apolipoprotein A1 or apolipoprotein B levels is regulated by apolipoprotein E variant rs429358 in patients with chronic schizophrenia.
Publication TypeJournal Article
Year of Publication2021
AuthorsRao W, Meng X, Li K, Zhang Y, Zhang XYang
JournalAnn Gen Psychiatry
Volume20
Issue1
Pagination56
Date Published2021 Dec 20
ISSN1744-859X
Abstract

BACKGROUND: The apolipoprotein E (ApoE) gene polymorphisms are correlated with blood lipid levels and several neuropsychiatric symptoms. Therefore, this study aimed to examine whether the ApoE rs429358 affected the development and clinical symptoms of schizophrenia and to explore the relationship between apolipoproteins levels and clinical symptoms.METHODS: The ApoE rs429358 was genotyped using a case-control design. The Positive and Negative Syndrome Scale (PANSS) was employed to evaluate the psychopathology of all patients.RESULTS: A total of 637 patients with schizophrenia and 467 healthy controls were recruited. We found no significant differences in the genotype and allele distribution between the patient and control groups. A significant correlation between PANSS negative symptoms and ApoA1 levels (p = 0.048) or ApoB levels (p = 0.001) was found in patients with schizophrenia, which was also confirmed by linear regression analyses (p = 0.048 vs. p = 0.001). Interestingly, only in the T homozygote group, ApoA1 and ApoB levels were predictors of the PANSS negative symptom score (p = 0.008 vs. p = 0.012), while in the C allele carrier group, no correlation was observed.CONCLUSIONS: This study found that the levels of ApoA1 and ApoB were negatively associated with negative symptoms of patients with schizophrenia. Furthermore, the association between ApoA1 or ApoB levels and psychopathology of schizophrenia was regulated by ApoE rs429358.

DOI10.1186/s12991-021-00376-w
Alternate JournalAnn Gen Psychiatry
PubMed ID34930329
PubMed Central IDPMC8686343
Grant List81371477 / / National Natural Science Foundation of China /
172777223 / / Key R&D Program of Science and Technology Department of Hebei Province /
361014 / / Government-funded Subsidy Project for Specialty Capacity-Building and Specialist Leaders /