6625 Boulevard Lasalle
Ashok Malla, MD FRCPC
Professor and Canada Research Chair (tier-1), Department of Psychiatry;
Adjunct Professor, Department of Epidemiology and Biostatistics,
Lead Investigator, ACCESS-Canada;
Clinician Scientist, Douglas Mental Health University Institute.
PEPP-Montréal and ACCESS-Canada
My research encompasses both the Psychosis as well as the Mental Health and Society platforms.
Briefly, my research has concentrated on the following domains within the psychosis field:
Early case identification and early intervention;
investigations examining predictors of and interventions to improve outcome in psychotic disorders;
Randomized controlled studies of early intervention models of service delivery;
Neuro-cognitive and neuro-biological aspects of negative symptoms and outcome;
Studies of cross-cultural differences in outcome in Psychosis;
State of ultra-high risk for psychosis (service delivery to prevent onset of psychosis; the role of stress and protective factors);
Global Mental Health and application of low cost models of service delivery and evaluation;
Research in transformation of youth mental health services in Canada
1. Malla AK, Norman RM. Prodromal symptoms in schizophrenia. Br J Psychiatry 1994; 164:487-93. (PMID: 8038937)
2. Malla AK, Norman RM, Manchanda R, Ahmed MR, Scholten D, Harricharan R, et al. One year outcome in first episode psychosis: influence of DUP and other predictors. Schizophr Res 2002; 54:231-42. (PMID: 11950548)
3. Malla AK, Norman RM, Manchanda R, Townsend L. Symptoms, cognition, treatment adherence and functional outcome in first-episode psychosis. Psychol Med 2002; 32:1109-19. (PMID: 12214790)
4. Malla AK, Norman RM, Takhar J, Manchanda R, Townsend L, Scholten D, et al. Can patients at risk for persistent negative symptoms be identified during their first episode of psychosis? J Nerv Ment Dis 2004; 192:455-63. (PMID: 15232315)
5. Malla A, Norman R, Scholten D, Manchanda R, McLean T. A community intervention for early identification of first episode psychosis: impact on duration of untreated psychosis (DUP) and patient characteristics. Soc Psychiatry Psychiatr Epidemiol 2005; 40:337-44. (PMID: 15902403)
6. Malla A, Payne J. First-episode psychosis: psychopathology, quality of life, and functional outcome. Schizophr Bull 2005; 31:650-71. (PMID: 16006593)
7. Malla A, Norman R, Schmitz N, Manchanda R, Bechard-Evans L, Takhar J, et al. Predictors of rate and time to remission in first-episode psychosis: a two-year outcome study. Psychol Med 2006; 36:649-58. (PMID: 16515734)
8. Malla A, Schmitz N, Norman R, Archie S, Roy P, Zipursky R. A multisite Canadian study of outcome of first-episode psychosis treated in publicly funded early intervention services. Can J Psychiatry 2007, 52(9): 563-71. (PMID: 17953160)
9. Béchard-Evans, L., Schmitz, N., Abadi, S., Joober; R., King, S., Malla, A.* (2007) Determinants of help-seeking and system related components of delay in the treatment of first-episode psychosis. Schizophrenia Research, 96(1-3): 206-14.
10. Iyer; S.N; Boekestyn, L; Cassidy, C; Joober; R; Malla, A.* (2008) Signs and symptoms in the pre-psychotic phase: description and implications for diagnostic trajectories. Psychological Medicine, 38(8): 1147 -56.
11. Cassidy, C.; Norman, R.; Manchanda, R.; Schmitz, N.; Malla, A.* (2009).Testing definitions of symptom remission in first episode psychosis for prediction of functional outcome at 2 years; Schizophrenia Bulletin, Schizophrenia Bulletin, (PMID: 19321629).
12. Anderson, K.K., Fuhrer, R., Malla, A.K.* (2010) The Pathways to Mental Health Care of First-Episode Psychosis Patients: A Systematic Review. Psychological Medicine.
13. Béchard-Evans, L., Iyer, S., Lepage, M., Joober, R. and Malla, A. (2009). Investigating cognitive deficits and symptomatology across pre-morbid adjustment patterns in first-episode psychosis. Psychological Medicine, (PMID: 19732482).
14. Bourque, F., van der Ven, E., Malla, A.* (2010). A Meta-analysis of the Risk for Psychotic Disorders among First and Second-Generation Immigrants. Psychological Medicine, (PMID: 20663257).
15. Malla, A.K., Bodnar, M., Joober, R., Lepage, M. (2011) Duration of Untreated Psychosis is associated with Orbital-frontal Grey Matter Volume Reductions in First Episode Psychosis. Schizophrenia Research. (PMID: 21059482).
16. Windell, D., Norman, R., Malla, A.* (2012). The personal meaning of recovery among individuals treated for a first episode of psychosis. Psychiatric Services, 63(6), 548-53. (PMID: 25549829).
17. Jordan, G., Lutgens, D., Joober, R., LePage, M., Iyer, S., Malla, A.* (2014). The relative contribution of cognition and symptomatic remission to functional outcome following treatment of a first episode psychosis. Journal of Clinical Psychiatry, 75(6), e566-72. (PMID: 25004197).
18. Malla, A., Jordan, G., Joober, R., Schmitz, N., Norman, R., Brown, T., Goldberg, K., Loohuis, H., Vracotas, N., Rochford, J. (2014). A Controlled Evaluation of a Targeted Early Case Detection Intervention for Reducing Delay in treatment of First Episode Psychosis. Social Psychiatry and Psychiatric Epidemiology. (PMID: 24902532).
19. Malla, A; Joober, R; Garcia, A (2015). 'Mental illness is like any other medical illness: A critical examination of the statement and its impact on patient care and society'. J Psychiatry Neuroscience, (40), 147-150.
Dr. Malla is a Professor of Psychiatry at McGill University, where he holds a Tier 1 Canada Research Chair in Early Psychosis, with a cross appointment in Department of Epidemiology and Biostatistics. Until July 2014, he has been the founding Director of the Prevention and Early intervention Program for Psychoses (PEPP-Montréal) at the Douglas Mental Health University Institute. He is currently an editor of the Journal of Social Psychiatry and Psychiatric Epidemiology. His clinical and research interests have been primarily related to pursuing the goal of understanding neurobiological, psychosocial and cross-cultural aspects of multidimensional outcome in psychotic disorders, with special emphasis on early phase psychosis and improving outcome through early intervention. He has conducted multidisciplinary research in schizophrenia and early psychosis, concentrating primarily on improving outcome. He has published more than 260 peer-reviewed articles, held numerous peer reviewed research grants from CIHR and NIH, supervised many graduate students, residents and fellows, and has been an advisor on program development and research in early intervention in psychotic disorders in several countries. He has recently been awarded a $25M grant as the lead investigator for a national research project on transformation of youth mental health services in Canada, funded jointly by CIHR and Graham Boekch Foundation under the Strategies for Patient Oriented Research (SPOR). He is also leading several global mental health projects in India, including one in Kashmir.
Cleghorn award for excellence in clinical research (2003);
Exemplary Psychiatrist award from Ami-Québec;
RO Jones awards for best papers (1995; 1996; 2011)
CNP Medal 2015
Drs Ridha Joober; Martin Lepage; Srividya Iyer; Jai Shah; Shalini Lal; Patricia Boksa; Marita Pruessner; Norbert Schmitz; Rebecca Fuhrer (all part of research in PEPP and ACCESS) plus all members of research staff at PEPP-Montréal (especially Sherezad Abadi coordinator) and at ACCESS.
In the news
Positive Changes Experienced After a First Episode of Psychosis: A Systematic Review. Psychiatr Serv. 2017:appips201600586.
"Worried about relapse": Family members' experiences and perspectives of relapse in first-episode psychosis. Early Interv Psychiatry. 2017.
Is the Clinical High-Risk State a Valid Concept? Retrospective Examination in a First-Episode Psychosis Sample. Psychiatr Serv. 2017;68(10):1046-1052.
Outcome in patients converting to psychosis following a treated clinical high risk state. Early Interv Psychiatry. 2017.
Bipolar disorder risk gene FOXO6 modulates negative symptoms in schizophrenia: a neuroimaging genetics study. J Psychiatry Neurosci. 2017;42(3):172-180.
What Is the Place of Clozapine in the Treatment of Early Psychosis in Canada? Can J Psychiatry. 2017;62(2):109-114.
Smoking status and its relationship to demographic and clinical characteristics in first episode psychosis. J Psychiatr Res. 2017;85:83-90.
Polygenic Risk Score associated with specific symptom dimensions in first-episode psychosis. Schizophr Res. 2017;184:116-121.
Longitudinal trajectory of clinical insight and covariation with cortical thickness in first-episode psychosis. J Psychiatr Res. 2017;86:46-54.
Recollection rejection of new items in individuals with first-episode psychosis. J Abnorm Psychol. 2016;125(1):104-13.
From early intervention in psychosis to youth mental health reform: a review of the evolution and transformation of mental health services for young people. Soc Psychiatry Psychiatr Epidemiol. 2016;51(3):319-26.
Adolescent vs. adult onset of a first episode psychosis: Impact on remission of positive and negative symptoms. Schizophr Res. 2016;174(1-3):183-8.
Post-traumatic growth following a first episode of psychosis: a scoping review. Early Interv Psychiatry. 2016.
Early Intervention for Psychosis in Canada: What Is the State of Affairs? Can J Psychiatry. 2016;61(3):186-94.
The effect of brexpiprazole in adult outpatients with early-episode schizophrenia: an exploratory study. Int Clin Psychopharmacol. 2016;31(6):307-14.
A study on negative and depressive symptom prevalence in individuals at ultra-high risk for psychosis. Early Interv Psychiatry. 2016.
The effect of second-generation antipsychotics on hippocampal volume in first episode of psychosis: longitudinal study. BJPsych Open. 2016;2(2):139-146.
Service Engagement in First-Episode Psychosis: Current Issues and Future Directions. Can J Psychiatry. 2015;60(8):341-5.
Investigation of white matter abnormalities in first episode psychosis patients with persistent negative symptoms. Psychiatry Res. 2015;233(3):402-8.
Cognitive insight in first-episode schizophrenia: further evidence for a role of the ventrolateral prefrontal cortex. Schizophr Res. 2015;166(1-3):65-8.