Animal Functional Magnetic Resonance Imaging: Trends and Path Toward Standardization.

TitleAnimal Functional Magnetic Resonance Imaging: Trends and Path Toward Standardization.
Publication TypeJournal Article
Year of Publication2019
AuthorsMandino F, Cerri DH, Garin CM, Straathof M, van Tilborg GAF, M Chakravarty M, Dhenain M, Dijkhuizen RM, Gozzi A, Hess A, Keilholz SD, Lerch JP, Shih Y-YIan, Grandjean J
JournalFront Neuroinform
Volume13
Pagination78
Date Published2019
ISSN1662-5196
Abstract

Animal whole-brain functional magnetic resonance imaging (fMRI) provides a non-invasive window into brain activity. A collection of associated methods aims to replicate observations made in humans and to identify the mechanisms underlying the distributed neuronal activity in the healthy and disordered brain. Animal fMRI studies have developed rapidly over the past years, fueled by the development of resting-state fMRI connectivity and genetically encoded neuromodulatory tools. Yet, comparisons between sites remain hampered by lack of standardization. Recently, we highlighted that mouse resting-state functional connectivity converges across centers, although large discrepancies in sensitivity and specificity remained. Here, we explore past and present trends within the animal fMRI community and highlight critical aspects in study design, data acquisition, and post-processing operations, that may affect the results and influence the comparability between studies. We also suggest practices aimed to promote the adoption of standards within the community and improve between-lab reproducibility. The implementation of standardized animal neuroimaging protocols will facilitate animal population imaging efforts as well as meta-analysis and replication studies, the gold standards in evidence-based science.

DOI10.3389/fninf.2019.00078
Alternate JournalFront Neuroinform
PubMed ID32038217
PubMed Central IDPMC6987455
Grant ListR01 MH111429 / MH / NIMH NIH HHS / United States
R01 NS091236 / NS / NINDS NIH HHS / United States
RF1 MH117053 / MH / NIMH NIH HHS / United States