Analysis of shared heritability in common disorders of the brain.

TitleAnalysis of shared heritability in common disorders of the brain.
Publication TypeJournal Article
Year of Publication2018
AuthorsAnttila V, Bulik-Sullivan B, Finucane HK, Walters RK, Bras J, Duncan L, Escott-Price V, Falcone GJ, Gormley P, Malik R et al.
Corporate AuthorsBrainstorm Consortium
JournalScience
Volume360
Issue6395
Date Published2018 06 22
ISSN1095-9203
Abstract

Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common variant risk, whereas neurological disorders appear more distinct from one another and from the psychiatric disorders. We also identified significant sharing between disorders and a number of brain phenotypes, including cognitive measures. Further, we conducted simulations to explore how statistical power, diagnostic misclassification, and phenotypic heterogeneity affect genetic correlations. These results highlight the importance of common genetic variation as a risk factor for brain disorders and the value of heritability-based methods in understanding their etiology.

DOI10.1126/science.aap8757
Alternate JournalScience
PubMed ID29930110
Grant ListR01 MH106490 / MH / NIMH NIH HHS / United States
U01 MH094432 / MH / NIMH NIH HHS / United States