Analyses of microstructural variation in the human striatum using non-negative matrix factorization.

TitleAnalyses of microstructural variation in the human striatum using non-negative matrix factorization.
Publication TypeJournal Article
Year of Publication2021
AuthorsRobert C, Patel R, Blostein N, Steele CC, Chakravarty MM
JournalNeuroimage
Volume246
Pagination118744
Date Published2021 Nov 27
ISSN1095-9572
Abstract

The striatum is a major subcortical connection hub that has been heavily implicated in a wide array of motor and cognitive functions. Here, we developed a normative multimodal, data-driven microstructural parcellation of the striatum using non-negative matrix factorization (NMF) based on multiple magnetic resonance imaging-based metrics (mean diffusivity, fractional anisotropy, and the ratio between T1- and T2-weighted structural scans) from the Human Connectome Project Young Adult dataset (n = 329 unrelated participants, age range: 22-35, F/M: 185/144). We further explored the biological and functional relationships of this parcellation by relating our findings to motor and cognitive performance in tasks known to involve the striatum as well as demographics. We identified 5 spatially distinct striatal components for each hemisphere. We also show the gain in component stability when using multimodal versus unimodal metrics. Our findings suggest distinct microstructural patterns in the human striatum that are largely symmetric and that relate mostly to age and sex. Our work also highlights the putative functional relevance of these striatal components to different designations based on a Neurosynth meta-analysis.

DOI10.1016/j.neuroimage.2021.118744
Alternate JournalNeuroimage
PubMed ID34848302