Altered neurochemical coupling in the occipital cortex in migraine with visual aura.
|Title||Altered neurochemical coupling in the occipital cortex in migraine with visual aura.|
|Publication Type||Journal Article|
|Year of Publication||2015|
|Authors||Bridge H, Stagg CJ, Near J, Lau C-ieong, Zisner A, M Cader Z|
|Date Published||2015 Oct|
BACKGROUND: Visual aura is present in about one-third of migraine patients and triggering by bright or flickering lights is frequently reported.METHOD: Using migraine with visual aura patients, we investigated the neurochemical profile of the visual cortex using magnetic resonance spectroscopy. Specifically, glutamate/creatine and GABA/creatine ratios were quantified in the occipital cortex of female migraine patients.RESULTS: GABA levels in the occipital cortex of migraine patients were lower than that of controls. Glutamate levels in migraine patients, but not controls, correlated with the blood-oxygenation-level-dependent (BOLD) signal in the primary visual cortex during visual stimulation.CONCLUSION: Migraine with visual aura appears to disrupt the excitation-inhibition coupling in the occipital cortex.
|Grant List||102584 / / Wellcome Trust / United Kingdom |
/ / Medical Research Council / United Kingdom