Age-related differences in brain activity in the subsequent memory paradigm: a meta-analysis.

TitleAge-related differences in brain activity in the subsequent memory paradigm: a meta-analysis.
Publication TypeJournal Article
Year of Publication2014
AuthorsMaillet D, Maria Rajah N
JournalNeurosci Biobehav Rev
Volume45
Pagination246-57
Date Published2014 Sep
ISSN1873-7528
KeywordsAging, Brain, Humans, Memory, Neural Pathways
Abstract

Healthy aging is associated with declines in episodic memory. This reduction is thought to be due in part to age-related differences in encoding-related processes. In the current study, we performed an activation likelihood estimation meta-analysis of functional magnetic resonance imaging (fMRI) studies assessing age-related differences in the neural correlates of episodic encoding. Only studies using the subsequent memory paradigm were included. We found age-related under-recruitment of occipital and fusiform cortex, but over-recruitment in a set of regions including bilateral middle/superior frontal gyri, anterior medial frontal gyrus, precuneus and left inferior parietal lobe. We demonstrate that all of the regions consistently over-recruited by older adults during successful encoding exhibit either direct overlap, or occur in close vicinity to regions consistently involved in unsuccessful encoding in young adults. We discuss the possibility that this overall pattern of age-related differences represents an age-related shift in focus: away from perceptual details, and toward evaluative and personal thoughts and feelings during memory tasks. We discuss whether these age-related differences in brain activation benefit performance in older adults, and additional considerations.

DOI10.1016/j.neubiorev.2014.06.006
Alternate JournalNeurosci Biobehav Rev
PubMed ID24973756
Grant ListMOP126105 / / Canadian Institutes of Health Research / Canada

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