Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria.

TitleAdvancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria.
Publication TypeJournal Article
Year of Publication2014
AuthorsDubois B, Feldman HH, Jacova C, Hampel H, Molinuevo JLuis, Blennow K, DeKosky ST, Gauthier S, Selkoe D, Bateman R, Cappa S, Crutch S, Engelborghs S, Frisoni GB, Fox NC, Galasko D, Habert M-O, Jicha GA, Nordberg A, Pasquier F, Rabinovici G, Robert P, Rowe C, Salloway S, Sarazin M, Epelbaum S, de Souza LC, Vellas B, Visser PJ, Schneider L, Stern Y, Scheltens P, Cummings JL
JournalLancet Neurol
Volume13
Issue6
Pagination614-29
Date Published2014 Jun
ISSN1474-4465
KeywordsAlzheimer Disease, Biomarkers, Humans, International Cooperation, Phenotype, Practice Guidelines as Topic, Societies, Medical
Abstract

In the past 8 years, both the International Working Group (IWG) and the US National Institute on Aging-Alzheimer's Association have contributed criteria for the diagnosis of Alzheimer's disease (AD) that better define clinical phenotypes and integrate biomarkers into the diagnostic process, covering the full staging of the disease. This Position Paper considers the strengths and limitations of the IWG research diagnostic criteria and proposes advances to improve the diagnostic framework. On the basis of these refinements, the diagnosis of AD can be simplified, requiring the presence of an appropriate clinical AD phenotype (typical or atypical) and a pathophysiological biomarker consistent with the presence of Alzheimer's pathology. We propose that downstream topographical biomarkers of the disease, such as volumetric MRI and fluorodeoxyglucose PET, might better serve in the measurement and monitoring of the course of disease. This paper also elaborates on the specific diagnostic criteria for atypical forms of AD, for mixed AD, and for the preclinical states of AD.

DOI10.1016/S1474-4422(14)70090-0
Alternate JournalLancet Neurol
PubMed ID24849862

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