Natalie Grizenko MD, FRCPC
6875 Boulevard LaSalle
Researcher, Douglas Research Centre
Medical Chief, Severe Disruptive Behaviour Disorders Program, Douglas Mental Health University Institute
Medial Chief, ADHD Clinic, Douglas Mental Health University Institute
Associate Professor, Department of Psychiatry, McGill University
Attention-deficit/hyperactivity disorder research
Dr. Natalie Grizenko is conducting research in :
- Pharmacogenetic and neuroimaging of ADHD (with Dr. Ridha Joober)
- Effectiveness of ADHD inteventions (with Dr.Lily Hechtman)
- Prenatal /postnatal risk factors in ADHD (including maternal stress and stress during pregancy and the impact of prenatal and postnatal complications).
- Epigenetic research in ADHD
- Day treatment effectiveness for children.
Sengupta, S.M., Fortier, M.-E., Thakur, G.A., Bhat, V., Grizenko, N., Joober, R. Parental psychopathology in families of children with Attention-Deficit/Hyperactivity Disorder and exposed to maternal smoking during pregnancy. Journal of Child Psychology and Psychiatry,2015; 56(2); 122-129
Grizenko, N., Cai, E., Jolicoeur, C., Ter-Stepanian, M., Joober, R., Effects of methylphenidate on acute math performance in children with attenti-deficit/hyperactivity disorder, Canadian Journal of Psychiatry, 2013; 58(10):632-639.
Grizenko, N., Pereira, R.M., Joober, R., Sensitivity of scales to evaluate change in symptomatology with psychostimulants in different ADHD subtypes. Canadian Journal of Child and Adolescent Psychiatry, 2013, 22(2):153-158.
Choudry, Z., Sengupta, S.M., Grizenko, N., Harvey, W.J., Fortier M.-E., Schmitz, N., Joober, R. Body Weight and ADHD: examining the role of self-regulation PLOS ONE, 8(1):e 55351.doi 10.1371/journal.pone.0055351 epub: Jan. 29, 2013.
Thakur, G., Sengupta, S.M., Grizenko, N., Choudry, Z., Joober, R., Comprehensive phenotype/genotype analysis of norepinephrine transporter gene (SL6A2) in ADHD: relationship to maternal smoking during pregnancy PLOS ONE, 2012:7(11):e49616, doi:10.1371/journal. pone.0049616. Epub 2012, Nov. 20.
Grizenko, N., Zhang, D.D.Q., Polotskaia, A., Joober, R., Efficacy of methylphenidate in ADHD children within the normal and gifted intellectual spectrum. J Can Academy of Child and Adolescent Psychiatry, 2012, 21(4):282-288.
Fortier, M.-E., Sengupta, S.M., Grizenko, N., Bellingham, J., Choudhry, Z., Joober, R. Genetic evidence for the association of the hypothalamic-pituatary-adrenal (HPA) axis with ADHD and methylphenidate treatment response Neuromolecular Medicine, Oct 10,2012, doi:10.1007/s12017-012-8202-1.
Choudry, Z., Sengupta, S.M., Grizenko, N., Fortier, M.-E., Thakur, G., Bellingham, J., Joober, R., Association between LPHN3 and ADHD disorder: interaction with maternal stress during pregnancy. J Child Psychol Psychiatry, 2012 Aug 53(8):892-902 doi:10.1111/j1469-7610.2012.02551x, Epub 2012, Apr. 7.
Grizenko, N., Fortier, M-E., Zadorozny, C., Thakur, G.A., Schmitz, N., Duval, R., Joober, R., Maternal stress during pregnancy, ADHD symptomatology in children and genotype: gene-environment interaction. J Can Academy.of Child and Adolescent Psychiatry.
Grizenko, N., Paci, M., Joober, R. Is the inattentive subtype of ADHD different from the combined/hyperactive subtype? Journal of Attention Disorders, 2010, 13(6): 649-657.
Grizenko, N., Rajabien Shayan, Y., Polotskaia, A., Ter-Stepanian, M., Joober, R. Maternal Stress during pregnancy and how it relates to symptom severity and response to treatment in children with ADHD. J. of Psychiatry and Neuroscience 2008, 33(1):10-16
Grizenko, N., Bhat, M., Schwartz, G., Ter-Stepanian, M., Joober, R. Therapeutic response to methylphenidate in children with attention deficit/hyperactivity disorder with and without learning disability. Journal of Psychiatry and Neuroscience, 2006, 31(1): 46-51.
Grizenko, N., Kovacina, B., Ben Amor, L., Schwartz, G., Ter-Stepanian, M., Joober, R. Relationship between response to methylphenidate treatment in children with ADHD and psychopathology in their families. J Am Acad Child Adolesc Psychiatry, 2006, 42(1): 47-53.
Grizenko, N., Zappitelli, M., Langevin, J.P., Hrychko, S., El-Messidi, A, Kaminester, D., Pawliuk, N. and Ter-Stepanian, M. Effectiveness of a Social Skills Training Program Using Self-Other Perspective Taking : A Nine Month Follow-up. Am J of Orthopsychiatry, 2000, 70(4): 501-509.
Grizenko, N. Outcome of a multimodal day treatment for children with severe behavior problems : A five year follow-up. J Am Acad Child Adolesc Psychiatry, 1997, 36(7) : 989-997.
From 2001 to 2015, Natalie Grizenko has assumed the position of medical director of the Child and Adolescent Psychiatry Program, with the tripartite mandate of integrating research, teaching and clinical excellence throughout the program. She has also been involved in clinical teaching and research assuming the role of postgraduate training coordinator in child psychiatry at the Douglas Institute from 1991 to 2001. She was also co-director of the Child Psychopathology Axis of the Douglas Research Center.
Dr. Grizenko has received (as principal investigator and associate investigator) over 66 grants totaling over $6 million. She has supervised 80 psychiatry residents, medical research students, Masters and Ph.D. students. Natalie Grizenko has published over 80 papers and book chapters, and has written two books.
Winner of the MHS/Keith Connors award for scholarly contributors, 2010.
Association between COMT methylation and response to treatment in children with ADHD. J Psychiatr Res. 2021;135:86-93.
Facing the Methodological Challenge in Dissecting the Genetics of ADHD: A Case for Deep Phenotyping and Heterogeneity Reduction. J Can Acad Child Adolesc Psychiatry. 2020;29(3):188-201.
by Epistatic Interaction in Modulating Behaviors in Children with ADHD: A Pharmaco-Dynamic Behavioral Approach. J Atten Disord. 2020:1087054720934191.
Therapeutic Response to Methylphenidate in ADHD: Role of Child and Observer Gender. J Can Acad Child Adolesc Psychiatry. 2020;29(1):44-52.
Acute blood pressure change with methylphenidate is associated with improvement in attention performance in children with ADHD. Prog Neuropsychopharmacol Biol Psychiatry. 2019;96:109732.
DRD3 Gene and ADHD: A Pharmaco-Behavioural Genetic Study. Neuromolecular Med. 2018.
DRD4 exon 3 genotype and ADHD: Randomised pharmacodynamic investigation of treatment response to methylphenidate. World J Biol Psychiatry. 2017:1-10.
Placebo response and its determinants in children with ADHD across multiple observers and settings: A randomized clinical trial. Int J Methods Psychiatr Res. 2017.
Locus-specific DNA methylation changes and phenotypic variability in children with attention-deficit hyperactivity disorder. Psychiatry Res. 2017;256:298-304.
Attention and Executive Function in Children Diagnosed with Attention Deficit Hyperactivity Disorder and Comorbid Disorders. J Can Acad Child Adolesc Psychiatry. 2017;26(1):21-30.
Apgar Scores Are Associated with Attention-Deficit/Hyperactivity Disorder Symptom Severity. Can J Psychiatry. 2016;61(5):283-90.
Increased Risk of Asthma in Children with ADHD: Role of Prematurity and Maternal Stress during Pregnancy. J Can Acad Child Adolesc Psychiatry. 2015;24(2):109-15.
The Effect of Maternal Stress during Pregnancy on IQ and ADHD Symptomatology. J Can Acad Child Adolesc Psychiatry. 2015;24(2):92-9.
Parental psychopathology in families of children with attention-deficit/hyperactivity disorder and exposed to maternal smoking during pregnancy. J Child Psychol Psychiatry. 2015;56(2):122-9.
Catechol-o-methyltransferase gene and executive function in children with ADHD. J Atten Disord. 2014;18(3):202-11.