6875 Boulevard Lasalle
Ph.D., FRSC, C.Q., C.M.
Co-Scientific Director, Ludmer Centre for Neuroinformatics and Mental Health
Researcher, Douglas Institute
Director, Sackler Program for Epigenetics & Psychobiology
James McGill Professor, Departments of Psychiatry and Neurology and Neurosurgery, McGill University
Biological basis of vulnerability for psychopathology
Biological basis of vulnerability for psychopathology
Biology of gene x environment Interactions
Epigenetic regulation of gene expression
Social influences on gene expression and brain development.
Environmental conditions during early development shape brain development. The Meaney lab idenfitied phenotypic variations in rodent models that derive from variations in maternal care. Maternal care stably modifies the epigenetic state and expression of genes implicated in behavioural and endocrine responses to stress and learning. These studies were the first to describe the influence of the social environment on genomic structure and function.
The Meaney lab is currently pursuing several lines of research, including:
• The molecular mechanisms by which environmental signals alter epigenetic mechanisms and gene expression in rodent models using a range of genome-wide analyses, including next generation sequencing.
• The effects of gene x environment interactions on epigenetic mechanisms in humans using longitudinal cohort studies.
• Epigenetic programming as a mechanism for the transgenerational transmission of traits in human and rodent models.
• The influence of extreme forms for childhood experience, such as abuse/neglect, on epigentic signals and genome function in relation to vulnerability for affective disorders.
Yehuda R, Daskalakis NP, Lehrner A, Desarnaud F, Bader HN, Makotkine J, Flory JD, Bierer LM, Meaney MJ. (2014) Influences of maternal and paternal PTSD on epigenetic regulation of the glucocorticoid receptor gene in Holocaust survivor offspring. American Journal of Psychiatry.
Bagot RC, Zhang TY, Wen XL, Nguyen TTT, Nguyen BH, Diorio J, Wong TP, Meaney, MJ. (2012) Variations in postnatal maternal care and the epigenetic regulation of Grm1 expression and hippocampal function in the rat. Proceedings of the National Academy of Sciences 109 Suppl. 2:17200-17207.
Meaney MJ, Ferguson-Smith A. (2010) Epigenomic regulation of the neural transcriptome: The meaning of the marks. Nature Neuroscience 13:1313-1318.
Michael J Meaney is a James McGill Professor of Medicine at Douglas Mental health University Institute of McGill University. He is the Director of the Maternal Adversity, Vulnerability and Neurodevelopment Project. Meaney also joined the Singapore Institute for Clinical Sciences in 2008 as a Senior Investigator and leads the Integrative Neuroscience Program. Meaney was educated at Loyola College of Montreal and received his PhD from Concordia University (Montreal) with post-doctoral training in Cell and Molecular Neurobiology at The Rockefeller University. Meaney’s primary research interest is that of the stable effects of early experience on gene expression and development, focusing on the influence of variations in maternal care. These studies have led to the discovery of novel epigenetic mechanisms for the influence of early experience. Meaney’s research is multidisciplinary and includes studies of behaviour and physiology, to molecular biology and genetics. He has authored over 375 journal articles. Graduates from Meaney’s lab holds faculty appointments across North America, Asia and Europe, including Columbia University, Queen’s University, University of California at Berkley, University of British Columbia, University of Michigan, University of Pennsylvania, the University of Toronto, INSERM (France) and the RIKEN Institute of Japan.
Margolese Brain Disorder Prize
This is the highest award for biomedical research, given by the Government of Quebec, which "goes to scientists whose research aims fall within the field of biomedicine. These fields include the medical sciences, the natural sciences, and engineering".
2014 Klaus J. Jacob Research Prize Laureate
The 2014 Klaus J. Jacob Research Prize Laureate has been awarded to Micheal Meany in recognition of his pioneering, cutting edge research on the biological mechanisms by which parental behaviour affects brain development and lifelong function. The Klaus J. Jacobs Awards is one of two international prizes presented to honour scientific achievements that are of exceptional social relevance in promoting the development of children and youth.The Jacobs Foundation attaches great importance to the practical application of scientific findings achieved through interdisciplinary research. The Klaus J. Jacobs Research Prize also includes an award of one million Swiss francs, (1M USD).
Member of the Order of Canada
The Member of the Order of Canada recognizes a lifetime of distinguished service in or to a particular community, group or field of activity
Fondation IPSEN International Prize in Neuronal Plasticity
It is awarded to researchers in recognition of outstanding contributions in the field of neuronal plasticity: development, synaptogenesis, aging, regeneration, grafts, growth factors.
Scientist of the year
The team from the radio show Les années lumière awarded the title of Radio-Canada Scientist of the Year 2009 to Michael Meaney and Gustavo Turecki for their discovery of the epigenetic effects of child abuse on the human brain.
Most Highly Cited Scientist in the area of neuroscience
He is recognized by the Institute for Scientific Information as a "Most Highly Cited Scientist" in the area of neuroscience.
Member of the Royal Society of Canada (RSC)
The Royal Society of Canada (RSC) is the senior national body of distinguished Canadian scholars, artists and scientists. It is Canada’s national academy. The primary objective of the RSC is to promote learning and research in the arts and sciences.
Knight of the National Order of Quebec
The National Order of Quebec is the highest recognition given by the government of Quebec.
Depression and Bipolar Support Alliance (DBSA) Awards Prestigious Klerman Prize to Innovators in Mental Health Research
Presidential Scholar by the University of California
He is honoured as the Presidential Scholar by the University of California at San Francisco.
NARSAD Distinguished Investigator Award
He is awarded this prestigious award in recognition of his contributions to stress research.
James McGill Chair
The James McGill Chair is awarded by McGill to advance and support the scholarship and research of exceptional academic staff in priority areas of intellectual interest.
Patricia R. Barchas Award
He is presented the Patricia R. Barchas Award in Sociophysiology in recognition of the importance and sophistication of his research, from the American Psychosomatic Society. The Patricia R. Barchas Award in Sociophysiology, established in 1999, is to memorialize Patricia Barchas by furthering the field of sociophysiology, the study of the reciprocal relationships that could lead to long-term change both in social behavior and in physiology.
CIHR Senior Scientist Career Award
This award is presented by the Canadian Institutes of Health Research (CIHR) for research on stress
Joseph W. Foley
Tie Yuan Zhang
Shantala Hari Dass
Thi Thu Thao Nguyen
The Influence of Gestational Diabetes on Neurodevelopment of Children in the First Two Years of Life: A Prospective Study. PLoS ONE. 2016;11(9):e0162113.
funtooNorm: an R package for normalization of DNA methylation data when there are multiple cell or tissue types. Bioinformatics. 2016;32(4):593-5.
The interplay of birth weight, dopamine receptor D4 gene (DRD4), and early maternal care in the prediction of disorganized attachment at 36 months of age. Dev Psychopathol. 2015;27(4 Pt 1):1145-61.
Sleep duration and growth outcomes across the first two years of life in the GUSTO study. Sleep Med. 2015;16(10):1281-6.
Neuroanatomic Differences Associated With Stress Susceptibility and Resilience. Biol Psychiatry. 2016;79(10):840-9.
Effects of Genotype and Sleep on Temperament. Pediatrics. 2015;136(4):e914-21.
Attachment disorganization among children in Neonatal Intensive Care Unit: Preliminary results. Early Hum Dev. 2015;91(10):601-6.
HIF3A association with adiposity: the story begins before birth. Epigenomics. 2015;7(6):937-50.
Association between perinatal methylation of the neuronal differentiation regulator HES1 and later childhood neurocognitive function and behaviour. Int J Epidemiol. 2015;44(4):1263-76.
Poor infant inhibitory control predicts food fussiness in childhood - A possible protective role of n-3 PUFAs for vulnerable children. Prostaglandins Leukot Essent Fatty Acids. 2015;97:21-5.
Breastfeeding and maternal sensitivity predict early infant temperament. Acta Paediatr. 2015;104(7):678-86.
Maternal childhood adversity and child temperament: an association moderated by child 5-HTTLPR genotype. Genes Brain Behav. 2015;14(3):229-37.
Effects of the Social Environment and Stress on Glucocorticoid Receptor Gene Methylation: A Systematic Review. Biol Psychiatry. 2016;79(2):87-96.
Maternal care differentially affects neuronal excitability and synaptic plasticity in the dorsal and ventral hippocampus. Neuropsychopharmacology. 2015;40(7):1590-9.
The maternal adversity, vulnerability and neurodevelopment project: theory and methodology. Can J Psychiatry. 2014;59(9):497-508.
Maternal prenatal felt security and infant health at birth interact to predict infant fussing and crying at 12 months postpartum. Health Psychol. 2015;34(8):811-9.
Spatial working memory and attention skills are predicted by maternal stress during pregnancy. Early Hum Dev. 2015;91(1):23-9.
Insights from the Growing Up in Singapore Towards Healthy Outcomes (GUSTO) cohort study. Ann Nutr Metab. 2014;64(3-4):218-25.
Establishment and consolidation of the sleep-wake cycle as a function of attachment pattern. Attach Hum Dev. 2015;17(1):23-42.
The methylated-DNA binding protein MBD2 enhances NGFI-A (egr-1)-mediated transcriptional activation of the glucocorticoid receptor. Philos Trans R Soc Lond, B, Biol Sci. 2014;369(1652).