6875 Lasalle Boulevard
Diane B. Boivin, MD, PhD
Professeure titulaire de psychiatrie, Faculté de Médecine, Université McGill,
Directrice, Centre d'étude et de traitement des rythmes circadiens
Study and Treatment of Circadian Rhythms
The Centre’s mission is to develop innovative solutions for circadian rhythms disorders. Our clinical research priorities are management of fatigue and sleep disturbances associated with atypical work schedules and jet lag. We also explore the disruptions of circadian clocks in these conditions and in several psychiatric and medical disorders.
Dr. Boivin’s research interests cover:
• Atypical work schedules maladaptation;
• Fatigue management risk systems for shift workers;
• Disruptions of circadian clocks in shift work and jet lag;
• Role of circadian rhythms in psychiatric and neurologic disorders;
• Interactions between the menstrual and circadian cycles;
• Circadian variation of cardiovascular functions.
1. M. Cuesta, N. Cermakian, D.B. Boivin Glucocorticoids entrain molecular clock components in human peripheral cells, Online: 2014, FASEB J fj.14-265686.
2. Boudreau P, Dumont GA, Boivin DB. Circadian Adaptation to Night Shift Work Influences Sleep, Performance, Mood and the Autonomic Modulation of the Heart. PloS ONE, 2013, 8(7).
3. Boudreau P, Dumont GA, Boivin DB. Circadian Variation of Heart Rate Variability across Sleep Stages. Sleep. 2013; 36(12):1919-28.
4. Shechter A, Lespérance P, Ng Ying Kin NMK, Boivin DB. Pilot investigation of the circadian plasma melatonin rhythm across the menstrual cycle in a small group of women with premenstrual dysphoric disorder. PloS ONE, 2012, 7(12).
5. Boudreau P, Brouse CJ, Dumont GA, Boivin DB, Sleep-wake and circadian-dependent variation in cardiorespiratory coherence, Proceedings, IEEE Eng Med Biol Soc 2012;1:3817-3820
6. Shechter A, Lespérance P, Ng Ying Kin NMK, Boivin DB. Nocturnal Polysomnographic Sleep across the Menstrual Cycle in Premenstrual Dysphoric Disorder. Sleep Med, 2012, 13 (8)1071-1078.
7. Boudreau P, Hsien Yeh W, Dumont G, Boivin DB. A circadian rhythm in heart rate variability contributes to the increased cardiac sympathovagal response to awakening in the morning, Chronobiol Int, 2012, 29(6):757-68.
8. Boivin DB, Boudreau P. Tremblay GM, Phototherapy and orange-tinted goggles for night shift adaptation of police officers on patrol, Chronobiol Int, 2012, 29(5) 629-640.
9. Boivin DB, Boudreau P, James FO, Ng Ying Kin N.M.K. Photic resetting in night shift work: impact on nurses sleep, Chronobiol Intl, 2012, 29(5):619-628.
10. Cermakian N, Waddington-Lamont E, Boudreau P, Boivin DB. Circadian Clock Gene Expression in Brain Regions of Alzheimer's Disease Patients and Control Subjects, J Biol Rhythms, 2011;26(2),160-170.
11. Shechter A, Boudreau P, Varin F, and Boivin DB. Predominance of distal skin temperature changes at sleep onset across menstrual and circadian phases. J Biol Rhythms, 2011, 26(3), 260-270.
12. Boudreau P, N.M.K Ng Ying Kin, Walker CD, Dumont G, Boivin DB. Correlation of Heart Rate Variability and Circadian Markers in Humans, Proceedings, IEEE Eng Med Biol Soc 2011:681-684.
13. Shechter A, Boivin DB. Sleep, hormones and circadian rhythms throughout the menstrual cycle in healthy women and women with premenstrual dysphoric disorder (PMDD) Int J Endocrinol, Special Issue on Sleep and the Endocrine Brain, 2010, 1-17
14. Shechter A, Varin F, Boivin DB. Circadian variation of sleep during the follicular and luteal phases of the menstrual cycle. Sleep, 2010; 33(5):647-56.
15. James FO, Cermakian N, Boivin DB. Circadian rhythms of melatonin, cortisol and clock gene expression during simulated night shift work. Sleep, 2007, 30(11):1427-36
Dr Diane. B. Boivin is Professor of Psychiatry at the Faculty of Medicine of McGill University and Founder/Director of the Centre for Study and Treatment of Circadian Rhythms at the Douglas Mental Health University Institute.
She completed her M.D. at Laval University in 1985 and conducts research as an expert in sleep and circadian rhythms since 1986. She obtained her Ph.D. in neurological sciences at University of Montreal in 1993. From 1992 to 1997, she completed a postdoctoral clinical/research fellowship in Boston in human chronobiology at the Brigham and Women’s Hospital, affiliated to Harvard Medical School. Her research interests cover: maladaptation to shift work and jet lag, fatigue risk management system for shift workers, the role of circadian rhythms in psychiatric and neurologic conditions, the relationships between the menstrual and circadian cycles, as well as the circadian variation of cardiovascular functions.
Throughout her career, she won multiple prizes and awards such as the Lieutenant Governor General Gold Medal Award for her Ph.D. thesis, the Young Investigator Award from the American Sleep Research Society, an Honorary Distinction Award for Specialized Medicine from the Association des Médecins de Langue Française du Canada and a total of 15 salary awards from agencies such as the Canadian Institute of Health Research (CIHR) and the Fonds de Recherche Québec-Santé Québec (FRQS)
During her career as a researcher, she has written over 300 scientific publications. Dr Boivin is Associate Editor for the journal Sleep, and an editorial board member for the journals Sleep Medicine, Chronobiology International, and Journal of Biological Rhythms. She is guest editor for the journal Sleep Medicine on a 2007 special issue on circadian rhythms disorders. In 2012, she published a book for the general public on sleep and its disorders entitled "Sleep and You. Sleep Better, Live Better." . This book serves as a useful clinical tool for the management of sleep disorders patients.
The book is available here:
Lieutenant Governor’s Gold Medal
Young Investigator Award from the American Sleep Research Society,
The Prix des médecins de cœur et d’action from the Association des médecins de langue française du Canada
A total of 15 salary awards from funding agencies such as the Canadian Institute of Health Research (CIHR) and the Fonds de recherche du Québec-Santé (FRQS)
Marc Cuesta, Ph.D.,- Post Doc
Philippe Boudreau, B.Ing.,Ph.D., - Post-Doc
Anna Koshy, M.Sc., Candidate
Johanne Gauthier, P.Eng., Research Coordinator
Alexandre Gervais, Research Assistant
Graduate Students( M.SC., Ph.D.) and Post doctoral Fellows
Simulated Night Shift Disrupts Circadian Rhythms of Immune Functions in Humans. J Immunol. 2016;196(6):2466-75.
Glucocorticoids entrain molecular clock components in human peripheral cells. FASEB J. 2015;29(4):1360-70.
Diurnal and circadian variation of sleep and alertness in men vs. naturally cycling women. Proc Natl Acad Sci USA. 2016;113(39):10980-5.
Identification of scalp EEG circadian variation using a novel correlation sum measure. J Neural Eng. 2015;12(5):056004.
Enhanced automated sleep spindle detection algorithm based on synchrosqueezing. Med Biol Eng Comput. 2015;53(7):635-44.
Impacts of shift work on sleep and circadian rhythms. Pathol Biol. 2014;62(5):292-301.
Improved spindle detection through intuitive pre-processing of electroencephalogram. J Neurosci Methods. 2014;233:1-12.